Substrates and inhibitors for cysteine protease ICH-1
US6288037A · kind A · utility
3Cited by
2References
21Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 18, 1996 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Jun 18, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.