Anti-viral guanosine-rich tetrad forming oligonucleotides
US6288042A · kind A · utility
19Cited by
16References
26Claims
0Family size
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Key dates
| Filing date | Feb 3, 1998 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Feb 3, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/335
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.