Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
US6288063A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 1998 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | May 27, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/192
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula EQU (T).sub.x A--B--D--E--G wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR1## the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents ##STR2## and with the proviso that when G is ##STR3## each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.