Substituted 3-cyanoquinolines

US6288082A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Allan Wissner · Monsey, US
• Hwei-Ru Tsou · New City, US
• Dan Maarten Berger · New City, US
• Middleton B. Floyd, Jr. · Suffern, US
• Philip Ross Hamann · Thiells, US
• Nan Zhang · San Diego, US
• Mark E. Salvati · Lawrenceville, US
• Philip Frost · Morristown, US

Key dates

• Filing date: Sep 24, 1999
• Grant date: Sep 11, 2001
• Expiry date: Sep 24, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds of formula I having the structure ##STR1## wherein G.sub.1, G.sub.2, R.sub.1, R.sub.4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.