Enantioselective alkylation of tricyclic compounds
US6288233A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2000 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Sep 21, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process for preparing a compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, and X.sup.5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula ##STR2## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, and X.sup.5 are as defined above, is treated with the following, in any sequence: PA1 (a) a non-nucleophilic strong base; PA1 (b) a chiral amino alcohol; and PA1 (c) a compound having the formula ##STR3## wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase. Also disclosed is a compound having the formula: ##STR4##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.