Multibinding inhibitors of microsomal triglyceride transferase protein
US6288234A · kind A · utility
56Cited by
6References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 4, 1999 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Jun 4, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/807
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 to 10 ligands covalently attached to one or more linkers. The multibinding compounds of this invention are useful for lowering serum lipid, cholesterol and/or triglyceride levels, and for preventing and treating disorders associated with hyperlipemia, hyperlipidemia, hyperlipoproteinemia, hypercholestrolemia, hypertriglyceridemia and the like, such atherosclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.