Modulation of cellular proliferation with thymidine phosphorylase

US6290953A · kind A · utility

Assignee

• Delta Biotechnology Limited · GB

Inventors

• David J. Ballance · Berwyn, US
• Michael COURTNEY · Achenheim, FR
• Christopher John Arthur Finnis · Nottingham, GB
• Darrell Sleep · Nottingham, GB

Key dates

• Filing date: Jan 11, 1996
• Grant date: Sep 18, 2001
• Expiry date: Jan 11, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of modulating cellular proliferation by the application of a thymidine phosphorylase to an organism. In a further aspect of the subject method, the thymidine phosphorylase is a conjugate which includes a targeting portion adapted to target the conjugate to a specific cell type or anatomical location. The thymidine phosphorylase has a thymidine phosphorylase activity of at least about 5%, preferably at least about 50% and, most preferably, at least about 90%, of the native E. coli enzyme.