Expandable gastro-retentive therapeutic system with controlled active substance release in the gastro-intestinal tract

US6290989A · kind A · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Bodo Asmussen · Bendorf, DE
• Karsten Cremer · Bonn, DE
• Hans-Rainer Hoffmann · Neuwied, DE
• Karin Ludwig · Datzeroth, DE
• Michael Roreger · Neuwied, DE

Key dates

• Filing date: Aug 31, 1999
• Grant date: Sep 18, 2001
• Expiry date: Aug 31, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.