Human phosphodiesterase type IVC, and its production and use
US6291199A · kind A · utility
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Key dates
| Filing date | May 15, 1998 |
| Grant date | Sep 18, 2001 |
| Priority date | — |
| Expiry date | May 15, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant human phosphodiesterase type IVC is described, and DNA coding for it. Particular conformers of the enzyme are identified, including a R- and S-rolipram stereoselective conformer which is obtainable by expression of human phosphodiesterase type IVC DNA in mammalian or insect cells. The recombinant enzyme may be used in a screen to select a compound capable of modulating the action of the enzyme, or as an immunogen to generate an antibody.
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