Nucleic acids containing modified human immunodeficiency virus genomes devoid of long terminal repeats encoding non-infectious, replication-deficient, immunogenic retrovirus-like particles

US6291227A · kind A · utility

Assignee

• Aventis Pasteur · CA

Inventors

• Joel Haynes · Bozeman, US
• Michel H. Klein · Willowdale, CA
• Benjamin Rovinski · Thornhill, CA
• Shi-Xian Cao · Mississauga, CA

Key dates

• Filing date: Mar 9, 1995
• Grant date: Sep 18, 2001
• Expiry date: Mar 9, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/924
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An immunogenic retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against retroviral infections, including AIDS and ATLL, is produced by genetic engineering. A DNA molecule comprising a retroviral genome devoid of long terminal repeats is incorporated into an expression vector, which is introduced into mammalian cells for expression of the retrovirus-like particle.