2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use

US6291494A · kind A · utility

Inventors

• Hakan V. Wikstrom · Mölndal, SE
• Per Andren · Uppsala, SE
• Per Arvid Emil Carlsson · Umeå, SE
• Durk Dijkstra · Bedum, NL
• Lars Gunne · Uppsala, SE
• Leonard Alexander Van Vliet · Groningen, NL

Key dates

• Filing date: Feb 9, 2001
• Grant date: Sep 18, 2001
• Expiry date: Feb 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins having general formula (1): wherein R.sub.1 and R.sub.2, which may be identical or different, are selected from the group consisting of a hydrogen atom, alkyl or haloalkyl groups of 1 to 7 carbon atoms, (alkyl)cycloalkyl groups of 3 to 7 carbon atoms, alkenyl or alkynyl groups of 3 to 6 carbon atoms, arylalkyl having 1 to 3 carbon atoms in the alkyl moiety, while the aryl nucleus may be substituted; and n and m are 1 or 2; and the enantiomers and the acid addition salts thereof, pharmaceutical compositions containing them and their use in the preparation of medicaments having an effect on the dopaminergic system of the central nervous system and/or the circulation. ##STR1##