2-cyclohexyl benzimidazole NMDA/NR2B antagonists

US6291499A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Wayne Thompson · Lansdale, US
• David A. Claremon · Audubon, US
• Peter M. Munson · Harleysville, US
• John A. McCauley · Maple Glen, US

Key dates

• Filing date: Oct 25, 2000
• Grant date: Sep 18, 2001
• Expiry date: Oct 25, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 4-substituted cyclohexanes substituted in the 1-position with 2-benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C.sub.1 -C.sub.4 alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective as NMDA NR2B antagonists useful for relieving pain.