Metal-binding cystein-free peptides for diagnostic and therapeutical purposes, methods for their production, and pharmaceuticals containing these compounds

US6291639A · kind A · utility

Assignee

• Institut fur Diagnosikforschung GmbH · DE

Inventors

• Jurgen Conrad · Berlin, DE
• Ludger Dinkelborg · Berlin, DE
• Sebastian Erber · Berlin, DE
• Cornelius Frommel · Zeuthen, DE
• Wolfgang Hohne · Bensberg, DE
• Wolfgang Kramp · Berlin, DE
• Gabriele Kuttner · Berlin, DE
• Reinhard Malin · Berlin, DE
• Hans-Martin Schier · Strausberg, DE
• Jens Schneider-Mergener · Berlin, DE
• Renate Steinbrecher · Walnut Creek, US

Key dates

• Filing date: Sep 20, 1996
• Grant date: Sep 18, 2001
• Expiry date: Sep 20, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

These invention relates to metal-complexing, cysteine-free peptides which may be coupled to an organ-specific probe directly or via a linker and are thus enriched as conjugates specifically in tumors, organs, tissues or centers of inflammation. The organ-specific probes used are, for example, antibodies or part-sequences of antibodies against tumor-associated antigens, e.g. the carcino-embryonal antigen (CEA, which are thus specifically enriched in tumors. The invention also relates to processes for producing the metal-complexing cysteine-free peptides and their conjugates. The present invention also relates to the use of the conjugates as components of a kit for in vivo diagnosis or in vivo therapy and radio-pharmaceuticals containing these conjugates together with radio-isotopes. The organ-specific conjugates are used to image tumors, organs or centers of inflammation.