Antiviral protease inhibitors

US6291687A · kind A · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Bjorn Classon · Stockholm, SE
• Ingemar Kvarnstrom · Linköping, SE
• Bengt Bertil Samuelsson · Skärholmen, SE

Key dates

• Filing date: Dec 14, 1999
• Grant date: Sep 18, 2001
• Expiry date: Dec 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I: ##STR1## wherein: PA1 A' and A" are independently the same or different group of the formula II: ##STR2## wherein: PA1 R' is H. CH.sub.3, C(CH.sub.3).sub.2, --OR.sup.a, --N(R.sup.a).sub.2, --N(R.sup.a)OR.sup.a or --DP PA1 R'" is H or CH.sub.3 ; R.sup.a is H, C.sub.1 -C.sub.3 alkyl; PA1 D is a bond, alkylene, --C(.dbd.O)--, --S(O)-- or --S(O).sub.2 --; PA1 P is an optionally substituted, mono or bicyclic carbo- or heterocycle; PA1 R" is H, any of the sidechains found in the natural amino acids, carboxacetamide, or a group (CH.sub.2).sub.n DP; PA1 M is a bond or --C(.dbd.O)N(R'")--; PA1 Q is absent, a bond, --CH(OH)-- or --CH.sub.2 --; PA1 or R" together with Q , M and R' define an optionally substituted 5 or 6 membered carbo- or heterocyclic ring which is optionally fused with a further 5 or 6 membered carbo- or heterocyclic ring; PA1 with the proviso that R' is --OR.sup.a, --N(R.sup.a).sub.2, --N(R.sup.a)OR.sup.a or --DP, if M is a bond and Q is absent; PA1 X is H, OH, OCH.sub.3 ; PA1 Y is H, OH, OCH.sub.3, but X and Y are not both H; PA1 Z' and Z" are independently --(CH.sub.2).sub.m P where P is as defined above; PA1 n and m are independently 0,1 or 2;…