Targeted hetero-association of recombinant proteins to multi-functional complexes

US6294353A · kind A · utility

Assignee

• MORPHOSYS AG · DE

Inventors

• Peter Pack · Unterföhring, DE
• Andrei Lupas · Unterhaching, DE

Key dates

• Filing date: Sep 23, 1997
• Grant date: Sep 25, 2001
• Expiry date: Sep 23, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.