Reverse-turn mimetics and methods relating thereto
US6294525A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1999 |
| Grant date | Sep 25, 2001 |
| Priority date | — |
| Expiry date | Sep 1, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70546
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: ##STR1## wherein A, R.sub.1, R.sub.2, R.sub.2a, R.sub.3, R.sub.3a and R.sub.4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.