Purine derivatives having phosphodiesterase IV inhibition activity

US6294541A · kind A · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• David Cavalla · Cambridge, GB
• Mark Chasin · Manalapan, US
• Peter Hofer · Liestal, CH
• Andre Gehrig · Basel, CH
• Peter Wintergerst · Basel, CH

Key dates

• Filing date: Oct 14, 1999
• Grant date: Sep 25, 2001
• Expiry date: Oct 14, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula: ##STR1## wherein PA1 R.sub.3 represent a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, alkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, alkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion is unsubstituted or substituted with OH, alkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; aryl which is unsubstituted or substituted with Cl, NH.sub.2, alkylamino, dialkylamino, amido, C.sub.1 -C.sub.8 alkylamido, C.sub.1 -C.sub.3 dialkylamido, OH, alkoxy, HC.dbd.NOH, HC.dbd.NOCONH.sub.2, C.sub.1 -C.sub.3 alkyl, phenyl or benzyl; aralkyl (C.sub.1-4); heterocyclyl; heterocyclylalkyl (C.sub.1 -C.sub.4); and heteroaryl; PA1 R.sub.8 represents H or a C.sub.1-8 alkyl which is unbranched or branched and unsubstituted or substituted with OH, alkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.3-8 cycloalkyl which is unsubstituted or substituted with OH, alkoxy, CO.sub.2 H, .dbd.NOH, .dbd.NOCONH.sub.2, or .dbd.O; C.sub.4-8 cycloalkylalkyl wherein the cycloalkyl portion …