Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6294558A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1999 |
| Grant date | Sep 25, 2001 |
| Priority date | — |
| Expiry date | Dec 15, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a compound of the formula: ##STR1## or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated five membered carbocyclic, wherein the 4-(sulfonyl)phenyl and the 4-substituted phenyl in the formula (I) are attached to ring atoms of Ring A, which are adjacent to each other; R.sup.1 is optionally substituted aryl or heteroaryl, with the proviso that when A is pyrazole, R.sup.1 is heteroaryl; R.sup.2 is C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, C.sub.1-4 alkylamino, C.sub.1-4 dialkylamino or amino; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen, halo, C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl or the like; or two of R.sup.3, R.sup.4 and R.sup.5 are taken together with atoms to which they are attached and form a 4-7 membered ring; R.sup.6 and R.sup.7 are independently hydrogen, halo, C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylamino or N,N-di C.sub.1-4 alkylamino; and m and n are independently 1, 2, 3 or 4. This invention also provides a pharmaceutical composition useful f…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.