Reverse hydroxamate inhibitors of matrix metalloproteinases

US6294573A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Michael L. Curtin · Pleasant Prairie, US
• Yujia Dai · Gurnee, US
• Steven K. Davidsen · Libertyville, US
• Joseph F. Dellaria · Woodbury, US
• Alan S. Florjancic · Kenosha, US
• Jianchun Gong · Deerfield, US
• Yan Guo · Westfield, US
• Howard R. Heyman · Deerfield, US
• James H. Holms · Gurnee, US
• Michael R. Michaelides · Gurnee, US
• Jamie R. Stacey · Racine, US
• Douglas H. Steinman · Morton Grove, US
• Carol K. Wada · Gurnee, US
• Lianhong Xu · Durham, US

Key dates

• Filing date: Jan 27, 2000
• Grant date: Sep 25, 2001
• Expiry date: Jan 27, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.