Process for preparing nifedipine

US6294673A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Mathias Berwe · Sprockhövel, DE
• Herbert Diehl · Leverkusen, DE
• Karl Rittner · Odenthal, DE
• Karl-Heinz Wahl · Erkelenz, DE
• Hans-Peter Wirges · Krefeld, DE

Key dates

• Filing date: Apr 26, 2000
• Grant date: Sep 25, 2001
• Expiry date: Apr 26, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the preparation of nifedipine by the reaction of methyl 2-(2-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate and the use of the nifedipine thus prepared for the production of a medicament.