Process for the preparation of Grignard reagents and novel Grignard reagents

US6296788A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Guido Giffels · Bonn, DE
• Guido Steffan · Odenthal, DE

Key dates

• Filing date: Jul 13, 2000
• Grant date: Oct 2, 2001
• Expiry date: Jul 13, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F3/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Grignard reagents which contain a protected aldehyde function are obtained in a particularly advantageous manner from a halogenated aldehyde by reaction with a secondary monoamine to give an open-chain aminal, and conversion of the latter into a Grignard reagent using metallic magnesium. The invention also relates to novel Grignard reagents of this type.