Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
US6297256A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2000 |
| Grant date | Oct 2, 2001 |
| Priority date | — |
| Expiry date | Jun 15, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are aryl and heteroaryl substitated pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABA.sub.A brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABA.sub.A brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABA.sub.A receptors in tissue samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.