Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
US6297400A · kind A · utility
3Cited by
1References
5Claims
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Key dates
| Filing date | Jul 2, 1999 |
| Grant date | Oct 2, 2001 |
| Priority date | — |
| Expiry date | Jul 2, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C.sub.15 H.sub.30 N.sub.2 O.sub.4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene)to yield the tetraamido macrocycle.
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