Method for improvement of radiation therapy of malignant tumors
US6299873A · kind A · utility
1Cited by
1References
5Claims
0Family size
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Key dates
| Filing date | Jun 16, 1999 |
| Grant date | Oct 9, 2001 |
| Priority date | — |
| Expiry date | Jun 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/5152
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of optimizing malignancy therapy includes surgical removal or reduction of the body burden of malignant cells and retention of some of those cells for subsequent use in immunotherapy. Boron neutron-capture therapy is employed at a radiation dosage below the threshold for normal tissue necrosis to provide preservation of normal tissue structure. Normal tissue tolerable limits are in the range of 10-13 GY-Eq. The removed tumor cells are altered by radiation or genetically to render them incapable of unlimited clonogenic propagation and then reinjected using multiple sequenced injections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.