Method for predicting the risk of prostate cancer morbidity and mortality

US6300060A · kind A · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Philip W. Kantoff · Brookline, US
• Myles Brown · Bladensburg, US
• Edward Giovannucci · Wakefield, US

Key dates

• Filing date: May 16, 1996
• Grant date: Oct 9, 2001
• Expiry date: May 16, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/118
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

There is described a method for prognosis of prostate cancer in a male comprising: (a) determining the length of the CAG trinucleotide repeat of exon 1 of the androgenic receptor gene and/or the length of the TA dinucleotide repeat of the 5 alpha reductase Type II gene or its complement obtained from DNA of the male and (b) correlating the length of the repeat with the aggressiveness and mortality risk of the cancer in the male.