Patent · US Expired

Protein/(poly)peptide libraries

US6300064A · kind A · utility

329Cited by

4References

25Claims

0Family size

Assignee

MORPHOSYS AG · DE

Inventors

Achim Knappik · Gräfelfing, DE
Peter Pack · Unterföhring, DE
Liming Ge · Munich, DE
Simon Moroney · Hersbruck, DE
Andreas Plückthun · Zürich, CH

Key dates

Filing date	Feb 18, 1998
Grant date	Oct 9, 2001
Priority date	—
Expiry date	Feb 18, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.