Acetamide derivative and use thereof
US6300337A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 2000 |
| Grant date | Oct 9, 2001 |
| Priority date | — |
| Expiry date | Aug 8, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present Invention relates to a novel acetamide derivative represented by the following Formula 1, which has an inhibition activity for chymotrypsin type proteases and is useful as an inhibitor for the above enzyme, especially as an inhibitor for chymase, and the use thereof as a medicine, for example, an antiasthma drug or a drug for curing vascular injuries complicated with angiogenesis and atheroma. ##STR1## wherein R.sup.0 represents a substituted or unsubstituted phenyl group, R.sup.1 represents an aryl group, a heteroaryl or an aliphatic lower alkyl group with or without substituents, R.sup.2 represents a substituted or unsubstituted alkyl, an aryl alkyl, a heteroaryl alkyl, and a heteroaryloxy alkyl or the like, J represents a carbonyl group, or a methylene group or the like, L represents a methoxy, hydroxyl or acetyloxy group or the like, X and Y independently represents a nitrogen atom or a carbon atom, Z represents a methylene group or a polyethylene group optionally having a substituent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.