Catalyzed fluorination of carbonyl compounds
US6300511A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 27, 2000 |
| Grant date | Oct 9, 2001 |
| Priority date | — |
| Expiry date | Mar 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method of substituting a carbonyl compound with fluorine at the .alpha.-position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results in replacement of a hydrogen atom by fluorine. The catalyst, which is used in a catalytically effective amount, is preferably a transition metal. In one class of methods the catalyst is a transition metal compound. In another class of methods, the catalyst is an elemental metal, in which case the carbonyl compound has an activating group attached to the carbon atom which is substituted by fluorine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.