Modular probe for total internal reflection fluorescence spectroscopy
US6300638A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 12, 1998 |
| Grant date | Oct 9, 2001 |
| Priority date | — |
| Expiry date | Nov 12, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/552
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An instrument for total internal reflection fluorescence spectroscopy having modular probe that inexpensively monitors vapors and liquid-phase analytes under field conditions is described. The system is particularly helpful in evaluating multiple analytes using the fluorescence of a material immobilized in a thin sorbent polymer coating. At the same time, the system is capable of monitoring trace quantities of analyte using a fluorescence-read immunological reaction. The device includes a diode laser source, a shaped optical element (which may be as simple as a microscope slide), and one or more amplified photodiode detectors. The shaped optical element propagates light from the diode laser in a series of internally reflective bounces.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.