Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6303136A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1999 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | Apr 12, 2019 |
Classification
- Technology area (CPC D)Textiles; Paper
- CPC primaryD04C1/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments twisted into a yarn or woven into a mesh, and can be in the form of a cylinder. When implanting the device, the semi-permeable membrane is preferably immunolsolatory, and the cells or tissue may produce a biologically active molecule to provide therapy. To enhance cell or tissue adhesion, the matrix is coated with extracellular matrix molecules or treated to provide a surface charge. The device can be made by inserting the matrix into a capsule formed of the semi-permeable membrane, distributing the cells or tissue on the matrix through an opening of the capsule, and sealing the opening of the capsule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.