Peptide probes and methods for making the same

US6303317A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Thomas Alber · Stuttgart, DE
• Victoria Allen · Berkeley, US
• Shivani Nautiyal · Portola Valley, US

Key dates

• Filing date: Jan 28, 1998
• Grant date: Oct 16, 2001
• Expiry date: Jan 28, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods for creating and using polypeptide probes with high affinity for any desirable coiled coil region are described, as well as heterospecific polypeptide probes directed to the coiled coil region of a target polypeptide. Core residue packing rules are provided for selective amino acid pairing and packing in the hydrophobic core of the interhelical interface.