Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia

US6303594A · kind A · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Linda Jolliffe · Montgomery, US
• William V. Murray · Montgomery, US
• Virginia Pulito · Flemington, US
• Allan Reitz · Lansdale, US
• Xiaobing Li · San Diego, US
• Linda Mulcahy · Flemington, US
• Cynthia Maryanoff · Robinson Township, US
• Frank J. Villani · Perkasie, US

Key dates

• Filing date: Mar 15, 2000
• Grant date: Oct 16, 2001
• Expiry date: Mar 15, 2020

Classification

• Technology area (CPC —): General

Abstract

This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.