3-oxo-2(H)-1,2,4-triazine derivatives as ligands of 5 HT1A receptors
US6303603A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2000 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | Apr 14, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns novel 3-oxo-(2H)-1,2,4-triazine derivatives of general formula (I) in which R.sub.1 represents: hydrogen, when A is an optionally substituted nitrogen atom; a linear or branched .sub.1 -C.sub.4 alkyl group; a C.sub.1 -C.sub.4 phenyl alkyl group, the phenyl ring being optionally substituted by one or several groups such as C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, trifluoromethyl. R.sub.2 represents: hydrogen; a linear or branched C.sub.1 -C.sub.4 alkyl radical; a C.sub.1-C.sub.4 phenyl or phenylalkyl group, the phenyl ring being optionally substituted by one or several groups such as C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, trifluoromethyl. A represents an oxygen atom or a nitrogen atom optionally NR.sub.3 substituted. R.sub.3 represents hydrogen or a methyl group. B represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl, pyridyl or pyrimidyl, optionally substituted by one or several groups such as C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, hydroxy, trifluoromethyl or halogen and n can be whole numbers ranging between 3 and 5; (IIb) in which Ar is as defined in formula (IIa) a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.