Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals
US6303613A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1998 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | Aug 19, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided novel compounds of formula (I) ##STR1## wherein: PA1 A represents a five membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S; or a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the Specification and pharmaceutically acceptable salts thereof and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.