Serotonin-like 9-substituted hypoxanthine and methods of use
US6303617A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 4, 1999 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | May 4, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 9-substituted hypoxanthine derivatives with unexpected physiological effects are disclosed. These compounds are of formula (I) where n is an integer from 1 to 6, R.sub.1 is selected from the group consisting of H, COOH, and COOW.sub.1, where W.sub.1 is selected from the group consisting of lower alkyl, amino, and lower alkylamino, and R.sub.2 is selected from the group consisting of H and OH. Among these compounds are N-(2-(5-hydroxyindol-3-yl)ethyl-3-6-oxyhydropurin-9-yl)propanamide, N-2-(indol-3-yl)ethyl)-3-(6-oxyhydropurin-9-yl)propanamide and N-(1-carboxyl)-(2-(5-hydroxyindol-3-yl)ethyl-3-(6-oxyhydropurin-9-yl)propa namide. These compounds have a number of utilities, including inhibition of the activity of monoamine oxidases, treating obesity, lowering serum cholesterol, and increasing the level of HDL cholesterol. Also disclosed are pharmaceutical compositions and methods of use of the derivatives to treat a number of disorders or conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.