Process for preparing benzylnitriles
US6303782A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 1, 2000 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | Mar 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): ##STR1## PA1 comprising treating a substituted aromatic compound of Formula (2.0.0): ##STR2## PA1 with a secondary nitrile of Formula (3.0.0): ##STR3## PA1 in the presence of a base having a pK.sub.a numerical value in the range of from about 17 to about 30, provided that the difference in pK.sub.a numerical values between said base and the corresponding tertiary nitrile of Formula (3.0.0) is no more than about 6; in an aprotic solvent having a dielectric constant (.di-elect cons.) of less than about 20; and at a reaction temperature in the range of from about 0.degree. C. to about 120.degree. C.; whereby there is formed said tertiary-nitrile-substituted aromatic compound final product of Formula (1.0.0); wherein the constituent parts W.sup.1, W.sup.2, W.sup.3, W.sup.4, and W.sup.5 ; and the substituent moieties R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 in the compounds of Formulas (1.0.0), (2.0.0) and (3.0.0) are selected from known organic groups and radicals as further detailed in the instant specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.