Method of improved magnetic resonance spectroscopic localization using spectral-spatial pulses
US6304084A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1998 |
| Grant date | Oct 16, 2001 |
| Priority date | — |
| Expiry date | Feb 6, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/446
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention uses spectral-spatial 180.degree. refocusing pulses in the point resolved spectroscopy (PRESS) localization sequence. The PRESS sequence uses a series of three pulses having a tilt angle pattern of 90.degree.-180.degree.-180.degree.. The first excitation pulses in the present invention is a spatially selective 90.degree. tilt angle pulse. The following two pulses are spectral-spatial refocusing pulses which provide multi-dimensional selectivity. This feature allows for enhanced solvent suppression, reduced chemical shift induced spatial displacement and an ability to refocus weakly coupled spins. In a preferred embodiment, the spectral-spatial pulses are time-asymmetric and identical, providing for a linear phase profile by means of phase compensation between the two refocusing pulses. Alternatively, a linear phase profile can be provided by using time-symmetric refocusing pulses. The time-asymmetric feature is preferred because it results in lower applied RF power and shorter echo times.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.