Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins

US6306306A · kind A · utility

Assignee

• Arzneimittelwerk Dresden GmbH · DE

Inventors

• Ulrich Voigt · Leipzig, DE
• Joachim Kinkel · Guldental, DE
• Roland Hempel · Radebeul, DE
• Roger-Marc Nicoud · Vandœuvre-lès-Nancy, FR

Key dates

• Filing date: Mar 21, 1997
• Grant date: Oct 23, 2001
• Expiry date: Mar 21, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.