Patent · US Expired

Transplacental delivery of oligonucleotides

US6306831A · kind A · utility

1Cited by
6References
10Claims
0Family size

Assignee

Inventors

Key dates

Filing dateSep 10, 1998
Grant dateOct 23, 2001
Priority date—
Expiry dateSep 10, 2018

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2310/346
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.