Cyclocarbamate and cyclic amide derivatives

US6306851A · kind A · utility

Assignees

• Amerimas Home Products, Inc. · US
• Ligand Pharmaceuticals Incorporated · US

Inventors

• Arthur A. Santilli · Havertown, US
• Andrew Q. Viet · Schwenksville, US
• Puwen Zhang · Audubon, US
• Andrew Fensome · Wayne, US
• Jay E. Wrobel · Lawrenceville, US
• James P. Edwards · San Diego, US
• Todd K. Jones · Solana Beach, US
• Christopher M. Tegley · Thousand Oaks, US
• Lin Zhi · San Diego, US

Key dates

• Filing date: Apr 19, 2000
• Grant date: Oct 23, 2001
• Expiry date: Apr 19, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compounds of the formula: ##STR1## PA1 wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C.sub.1 to C.sub.6 alkyl group; R.sub.1 and R.sub.2 are independent substituents selected from the group of H, C.sub.1 to C.sub.6 alkyl, substituted C.sub.1 to C.sub.6 alkyl, C.sub.2 to C.sub.6 alkenyl, substituted C.sub.2 to C.sub.6 alkenyl, C.sub.2 to C.sub.6 alkynyl, substituted C.sub.2 to C.sub.6 alkynyl, C.sub.3 to C.sub.8 cycloalkyl, substituted C.sub.3 to C.sub.8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, COR.sup.A, or NR.sup.B COR.sup.A ; or R.sup.1 and R.sup.2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to three heteroatoms selected from the group of O, S and N; or pharmaceutically useful salts thereof. The compounds of this invention are useful as agonists and antagonists of the progesterone receptor and in methods of inducing contracep…