Thienopyrancecarboxamide derivatives
US6306861A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 2000 |
| Grant date | Oct 23, 2001 |
| Priority date | — |
| Expiry date | Jul 28, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is directed to compounds of Formula I: ##STR1## wherein PA1 R is an aryl, cycloalkyl or polyhaloalkyl group, PA1 R.sub.1 is chosen from the group consisting of alkyl, alkoxy, polyfluoroalkoxy, hydroxy and trifluoromethanesulfonyloxy; each of R.sub.2 and R.sub.3 independently is chosen from the group consisting of a hydrogen, halogen, alkoxy and polyfluoroalkoxy group, and n is 0, 1 or 2. The invention further provides pharmaceutical compositions comprising a compound of Formula I or a N-oxide or pharmaceutically acceptable salt of such a compound in admixture with a pharmaceutically acceptable diluent or carrier. In another aspect, the present invention is directed to methods for selectively preventing contractions of the urethra and lower urinary tract, without substantially affecting blood pressure, by administering one or more selected compounds of Formula I to a mammal (including a human) in need of such treatment in an amount or amounts effective for the particular use. In yet another aspect, the invention is directed to methods for blocking .alpha..sub.1 receptors, by delivering to the environment of said receptors, e.g., to the extracellular medium, (or by admi…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.