Activated iododerivatives for the treatment of cancer and AIDS
US6306871A · kind A · utility
2Cited by
2References
4Claims
0Family size
Inventors
Key dates
| Filing date | Sep 19, 2000 |
| Grant date | Oct 23, 2001 |
| Priority date | — |
| Expiry date | Sep 19, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D285/135
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer cell and virus replication is through inhibition of the binding of transcription factors to zinc finger binding domains. The compounds are effective in inhibiting growth of a variety of human and animal tumor and leukemia cell lines at low concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.