Pharmaceutical compositions containing hydroximic acid derivatives
US6306878A · kind A · utility
Inventors
Key dates
| Filing date | Sep 27, 1996 |
| Grant date | Oct 23, 2001 |
| Priority date | — |
| Expiry date | Sep 27, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genom and/or mitochondrium from damages or for the treatment of diseases connected with such damages, said compositions comprising a hydroximic acid derivative of the formula: ##STR1## wherein PA1 R.sup.1 represents a hydrogen or a C.sub.1-5 alkyl group, PA1 R.sup.2 stands for a hydrogen, a C.sub.1-5 alkyl group, a C.sub.3-8 cycloalkyl group or a phenyl group optionally substituted by a hydroxy or a phenyl group, or PA1 R.sup.1 or R.sup.2 together with the nitrogen atom they are attached to form a 5 to 8 membered ring optionally containing one or more further nitrogen, oxygen or sulfur atom(s) and said ring can be condensed with another alicyclic or heterocyclic ring, preferably a benzene, naphthalene, quinoline, isoquinoline, pyridine or pyrazoline ring, furthermore, if desired and chemically possible, the nitrogen and/or sulfur heteroatom(s) are present in the form of an oxide or dioxide, PA1 R.sup.3 means a hydrogen, a phenyl group, a naphthyl group or a pyridyl group wherein said groups can be substituted by one or more halo atom(s) or C.sub.1-4 alkoxy group(s), PA1 Y is a hydro…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.