Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
US6309639A · kind A · utility
52Cited by
22References
2Claims
0Family size
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Key dates
| Filing date | Aug 9, 2000 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Aug 9, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [.sup.3 H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
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