Composition with sustained release of active principle, capable of forming a microemulsion
US6309665A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2001 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Feb 2, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/4866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a composition comprising a microemulsion forming system by contact with a hydrophilic phase brought, after ingestion, by the physiological fluid, said microemulsion forming system comprising: at least an active principle; a lipophilic phase; a surfactant (TA); a co-surfactant (CoTA). The invention is characterized in that said composition further comprises an inert polymeric matrix which cannot be ionised at physiological pH, dispersed in the microemulsion forming system before ingestion, said polymeric matrix being capable, after ingestion, of forming on contacting the physiological fluid, a gelled polymeric matrix enabling to release by diffusion, in continuous and prolonged manner the already micro-emulsified active principle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.