Method for removing N-terminal methionine
US6309859A · kind A · utility
14Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1999 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Nov 9, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal. The method reacts a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal with an .alpha.-diketone derivative, followed by hydrolysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.