Sequestrin of Plasmodium falciparum
US6310046A · kind A · utility
12Cited by
3References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 17, 1995 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Nov 17, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In this application is described the expression cloning and functional characterization of the CD36-binding domain of Sequestrin. Sequestrin is a surface protein of 215-250 kD size which does not vary in size between parasite strains. The Sequestrin gene appears to be single-copy-number within the genome; noncytoadherent laboratory parasite strains carry the sequestrin gene but fail to express the protein. Sequestrin binds with high affinity to CD36. Sequestrin protein and sequence can be used as a diagnostic, prognostic, and therapeutic tool.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.