Use of chelating agents in the treatment of atherosclerotic conditions

US6310051A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Jan-Olof Karlsson · Oslo, NO
• Rolf Goran Gustav Andersson · Vikingstad, SE
• Anders Olsson · Stockholm, SE
• Bo Zieden · Norrköping, SE
• Per Jynge · Trondheim, NO
• Tudor Griffith · Cardiff, GB
• Derek Grant · Lillestrøm, NO
• Robertson Towart · Stoke Poges, GB
• Helge Refsum · Oslo, NO

Key dates

• Filing date: Jun 23, 2000
• Grant date: Oct 30, 2001
• Expiry date: Jun 23, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R.sup.1 independently represents hydrogen or --CH.sub.2 COR.sup.5 ; R.sup.5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R.sup.2 independently represents a group XYR.sup.6 ; X represents a bond, or a C.sub.1-3 alkylene or oxoalkylene group optionally substituted by a group R.sup.7 ; Y represents a bond, an oxygen atom or a group NR.sup.6 ; R.sup.6 is a hydrogen atom, a group COOR.sup.8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR.sup.8, CONR.sup.8.sub.2, NR.sup.8.sub.2, OR.sup.8, .dbd.R.sup.8, .dbd.O, OP(O)(OR.sup.8)R.sup.7 and OSO.sub.3 M; R.sup.7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R.…