2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors

US6310060A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Stephen Douglas Barrett · Hartland, US
• Alexander James Bridges · Saline, US
• Donna Reynolds Cody · Saline, US
• Annette Marian Doherty · Ann Arbor, US
• David T. Dudley · Ann Arbor, US
• Alan R. Saltiel · Ann Arbor, US
• Mel C. Schroeder · Dexter, US
• Haile Tecle · Ann Arbor, US

Key dates

• Filing date: Jan 5, 2000
• Grant date: Oct 30, 2001
• Expiry date: Jan 5, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen or substituent groups such as alkyl, and where R.sub.7 is hydrogen or an organic radical, and Z is COOR.sub.7, tetrazolyl, CONR.sub.6 R.sub.7, or CH.sub.2 OR.sub.7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.