Substituted amino acids as erythropoietin mimetics

US6310078A · kind A · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Peter J. Connolly · New Providence, US
• Victor T. Bandurco · Bound Brook, US
• Steven K. Wetter · Flemington, US
• Sigmond Johnson · Flemington, US
• Jacqueline Bussolari · Skillman, US
• William V. Murray · Montgomery, US

Key dates

• Filing date: Mar 3, 2000
• Grant date: Oct 30, 2001
• Expiry date: Mar 3, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to a series of substituted amino acids of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.